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In six episodes, 4 Blocks tells a story about friendship, family, betreyal and guilt in the milieu of an arabic clan in Berlin-Neuköln. The story centers around the charismatic and ambitious Ali Hamady (Kida Khodr Ramadan), who uses every method to promote the business of his family. But when his brother-in-law gets arrested during a raid, Ali looses more and more control over the business, the family and his 4 blocks.

A man wakes up in the middle of a vineyard, unconscious. He has lost all memory of his past life and he can no longer remember his name. In addition to the man lies the corpse of a young woman who, as it later turns out, is the wine queen of the village.

The unemployed Arthur Ahnepol, played by one of Germany's most popular actors Jan Josef Liefers ekes out a bleak existence. Drawn from the strains of his unhappy marriage and bored to death, he makes a morbid plan: He wants his obnoxious wife to die. With the money from the life insurance there's no obstacle for a restart with his beloved. But an unwritten law dominates the life of the unlucky fellow: Every problem solved by Arthur has a far worse effect. And so, he sets off an avalanche of disastrous events.