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The series takes viewers to the epicenter of America's struggle with opioid addiction, from the boardrooms of Purdue Pharma, to a distressed Virginia mining community, to the hallways of the DEA.

A one-hour drama that follows a group of diverse agents - from the Drug Enforcement Agency (DEA), Federal Bureau of Investigations (FBI) and U.S. Customs - whose worlds collide while forced to live together in an undercover beach house in Southern California.

Sofia discovers that her husband has links to drug trafficking and decides to cooperate with the DEA. Threatened, she must go to Spain with her daughter to start a new life.

Not much is known about the Drug Enforcement Administration and what it is that they do. DEA will give viewers a glimpse into how the organization works and follow a group of special agents and a task force in the DEA's Detroit division.