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Live-action series adaptation of Haro Aso's Alice in Borderland (Imawa no Kuni no Alice) manga. The manga centers on Ryōhei Arisu (pronounced the same as "Alice" in Japanese), a male high school student who is irritated with his intolerable everyday life. One night, he tags along with his bad friends Karube and Chōta to hang out in town. However, the town is suddenly covered in giant fireworks. When he comes to his senses, Ryōhei notices that no one else is around. Finding themselves in a different world, Ryōhei, Karube, and Chōta are forced to participate in survival games or die right off the bat. The three fight to live, as well as to find a way back to their own world.

After graduating from the University of Traditional Chinese Medicine, Sun Jiayou returned home to inherit a traditional Chinese medicine shop. He found that although the people here would not use medicine as a treatment. They had own spiritual system. To realize his grandfather's dream, he plans to promote Chinese medicine in a different world. But the spirit messenger considers it a big threat. In some confrontations with the spirit messenger, he discovers a greater mystery.