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In the near future, superpowered exoskeletons called Infinite Stratos (IS) can only be piloted by women, which has revolutionized society. Ichika Orimura, younger brother of a famous pilot, is the first male who can pilot an IS, so he is forced to attend an all-girls' school and train under the scrunity of the government and his older sister, a teacher at the academy.

As cyborg terrorist Doc Terror and his machine minion Hacker continue with their malevolent machinations, Max Ray, Jake Rockwell and Ace McCloud, Centurions, remain at the ready. Masters of land, sea and air, the trio uses the fantastic abilities granted to them by their exo-frame battlesuits - Power Xtreme! - to become more than man and more than machine. With the brilliant Crystal Kane directing operations from aboard their orbiting satellite station, Skyvault, Ace, Jake and Max teleport across time and space, challenging Doc Terror and confronting the unknown.