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A classroom taught by Ms. Valerie Frizzle is always fun and exciting. The colorful teacher owns a Magic School Bus which can transform into different things like a spaceship, a battery, or even an alligator! These things can help Ms. Frizzle with visual teaching methods as she reveals information about anything in science. The students include Carlos, Phoebe, Keesha, Dorothy Ann, Tim, Ralphie, Arnold, and Wanda. Originally, The Magic School Bus aired on PBS. But when production ceased after four years, The Magic School Bus's run on PBS ended with it.

Ms. Frizzle and her class along with an inventive high-tech bus that invites children on high-flying hijinks that introduce the incredible world of science.