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Iride Akatsuki and seven other charismatic game streamers wake up in the world of a mysterious free-to-play game called Naka no Hito Genome. Now they are competing in real-life games with life-or-death stakes, but clearing several game tasks could earn them 100 million lives.

This is an anime adaptation of Chunsoft's visual novel mystery game 428 Fuusa Sareta Shibuya de. The story concentrates on Canaan a mysterious female mercenary in Shanghai who gets caught up in a starnge conspiracy.