The show follows the experienced Dr. Michelle Oakley, veterinarian, as she makes house calls across thousands of square miles in the Yukon helping many species of animals, including an angry muskox, a caribou with a tumor, a defensive mama lynx, and a grey owl with an amputated wing. Accompanied by her teenage daughters and armed with humor as sharp as a scalpel, Dr. Oakley deftly juggles being a full-time veterinarian, wife and mom while taking us into the isolated regions of the Yukon.