Stationed in every tendril of a busy downtown trauma center and thrust into front line medical action, Nurses sees four recent graduates beginning their careers in a high-stakes hospital with pressure cooker training. Forming an inextricable bond, the nurses struggle to find a work-life balance that matches and counters the intensity of their new job. Their interaction with patients, relatives, and staff quickly leads them to the discovery that nursing isn't just about biology, chemistry, and anatomy, it's also about psychology, compassion, and romantic complications.