The series follows the chaotic and violent struggle to control wealth and power in the North American fur trade in the late 18th century. Told from multiple perspectives, the series takes place in a world where business negotiations might be resolved with close-quarter hatchet fights, and where delicate relations between native tribes and Europeans can spark bloody conflicts.
The setting: downtown New York in 1900, a tumultuous time of massive change and great progress. The series centers around the groundbreaking surgeons, nurses and staff at Knickerbocker Hospital, who are pushing the bounds of medicine in a time of astonishingly high mortality rates and zero antibiotics.