Show centers on Nova Bordelon (Rutina Wesley), a formidable journalist and activist based in New Orleans. Her life, and that of her brother and their extended family, undergoes significant change when her sister, Charley, returns to Louisiana from Los Angeles to help run the family sugarcane farm.

Dr. Quinn, Medicine Woman was a show that focused on Dr. Mike, a woman doctor in a time when that was unheard of. It started with her journey to Colorado Springs to be the town's physician after her father's death in 1868.