The Devil's Woman tells the story of Natalia Vallejo, an elementary school teacher with dreams of leaving her town to pursue a tourism career, and Cristo Beltrán, a high-ranking criminal who appears to be the benefactor of the town. When he becomes obsessed with Natalia although she is in love with another man, he does the unimaginable to seduce her.
Fernanda vows revenge after her husband is murdered and she is violated on her wedding night. With a poor memory of that traumatic night, Fernanda mistakes her true love Rafael for the man who ruined her life - Rafael's father.