Vanessa Helsing, distant relative of famous vampire hunter Abraham Van Helsing, is resurrected only to find that vampires have taken over the world. She is humanity's last hope to lead an offensive to take back what has been lost.

The show centers on a deep-cover operative named Martin Odum, who has an uncanny ability to transform himself into a different person for each job. But his own identity comes into question when a mysterious stranger suggests that Martin isn't who he thinks he is.

Alan Ball, creator of Six Feet Under, returns to HBO with a new series based on the novel series Southern Vampire by Charlaine Harris. The series follows the world of vampires who co-exist with humans in Louisiana by drinking a Japanese-made synthetic blood.