Louis C.K. stars as Horace and Steve Buscemi is Pete, who run a bar together; Alan Alda is their grizzled, racist uncle (also named Pete), and other comedians, actors, and Louie friends such as Nick DiPaolo, Kurt Metzger, Steven Wright, Jessica Lange.

This is a comedy filtered through the observational humor of Louis C.K. Each episode puts a spotlight on Louie's hectic life as a successful stand-up comedian and newly single father raising his two daughters. The single-camera comedy is a mix of Louis C.K.'s stand-up comedy and scripted short films.

Family comedy focusing on a middle-class couple raising their only child. As sexual politics play out, with the father wanting more sex but not wanting to give in to his wife, who's itching to have another baby, he tries arranging it so their daughter will have at least one Black friend.