When the President, VP, and Cabinet all meet in one location for an event such as the State of the Union, one Cabinet member is conspicuously missing: the Designated Survivor. Hidden away in an undisclosed location with Presidential-level security, the Designated Survivor is ready to take the reins of the President should the unthinkable happen and the rest of the government is wiped out in an attack.

A psychological thriller revolving around two detectives, Beth and Jack (Dylan McDermott), who handle stalking incidents for the Threat Assessment Unit of the LAPD. McDermott's Jack Larsen is a recent transfer from Robbery Homicide from New York. His healthy confidence and quick thinking has gotten him into trouble in the past - a past he hopes to leave behind.

Nikita is based on the original French film La Femme Nikita. The story is about two assassins for a top-secret government organization assassin who goes rogue and a new assassin who is training to replace the old one.