The series follows the two as they confine themselves to America's most terrifying places for an unprecedented 72 hours straight, per the Discovery Communications cable channel. Living at haunted locations, many of which have never before been seen on television, with some being investigated for the first time ever. Groff and Weidman believe that the longer they stay, the more the spirits will communicate with them and the more information they can gather about the unknown.

Shepherdstown is renowned for being the oldest town in West Virginia. It is also quietly referred to as the most haunted town in America, because it has always been home to inexplicable hauntings, bizarre accidents and unsolved crimes. In a town of 1,700 residents, almost every single person has had an experience with the supernatural. Now, a surge of supernatural activity has forced the local police to partner with members of the paranormal community to help solve some of the town's deepest mysteries.

Three ghost hunters Zak Bagans, Nick Groff, and Aaron Goodwin set out in search of spirits while armed with nightvision cameras and digital recorders on this paranormal show based on the Sci-Fi channel documentary.