Chambers centers on a young heart attack survivor who becomes consumed by the mystery surrounding the heart that saved her life. However, the closer she gets to uncovering the truth about her donor's sudden death, the more she starts taking on the characteristics of the deceased - some of which are troublingly sinister.
This is described as a grounded character-driven drama based on Wolitzer's novel about a group of friends who meet at an arts camp when they're 15 in 1974. The series chronicles their relationships throughout the next three decades dealing with the great expectations of youth juxtaposed with the realities life hands you as you get older.