Space Cases is about five space cadets, their two teachers and a malfunctioning android, Thelma. After the children see an alien spaceship, the Christa, outside their Space Academy and board it they become lost in space, with their assistant principal and teacher.
A team of teenagers with attitude are recruited and try save Angel Grove from the evil witch Rita Repulsa and later Lord Zedd Emperor of all he sees and their horde of monsters.