This show follows Reverend Jesse Custer, a small-town Texas minister on the verge of losing his faith when he merges with a spiritual force called Genesis - making him more mighty than the Almighty. Able to command the obedience of those who hear his words and joined by his gun-toting girlfriend Tulip and the hard-drinking Irish vampire Cassidy, Custer begins a violent journey across the country in search of answers from a disenfranchised God.