Adapted from the 2016 Marvel comic book series of the same name, Moon Girl and Devil Dinosaur follows the adventures of 13-year-old Lunella Lafayette - one of the smartest people in the world, although not everyone believes her - and Devil, her pet dinosaur, who arrived in the present day thanks to an accidental time vortex. The concept is an updated take on Captain America and X-Men co-creator Jack Kirby's 1978 Devil Dinosaur comic book series.
Having gone missing seven years ago, the previously blind Prairie returns home, now in her twenties with her sight restored. While many believe she is a miracle, others worry that she could be dangerous.